Institute for Biomedical Sciences
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Baozhong Wang

Baozhong Wang

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Baozhong Wang

Faculty    Distinguished University Professor    Institute for Biomedical Sciences

Overview

Education

Ph.D., Molecular Biology and Biochemistry, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China, 2003.

Biography

Baozhong Wang, Distinguished University Professor at Georgia State University's Institute for Biomedical Sciences, is focused on the interaction of viral pathogens with the host immune system. He studies how viral antigens (particularly influenza and HIV antigens) trigger immune responses, with specific emphasis at the crossroads of vaccines and bioengineering through the use of protein nanotechnology and controlled releases in vaccine development.

Baozhong Wang earned his Ph.D in Molecular Biology and Biochemistry from Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences in 2003.

Research Interests

Innate and adaptive immune responses are both important for a successful protective immunity. My laboratory is focused on understanding how viral pathogens trigger and evade host immune responses, and it designs vaccines integrating both innate triggers and immunogens in nanoparticulate platforms as mimicries of virions. We are also interested in the application of the newest bioengineering technology, including nanotechnology and controlled release technology, in vaccine development.

Publications

Publications

Selected Publications:

  • Kim JK, Zhu W, Dong C, Wei L, Ma Y, Denning T, Kang SM, Wang BZ. Double-layered protein nanoparticles conjugated with truncated flagellin induce improved mucosal and systemic immune responses in mice. Nanoscale Horiz. 2024 Sep 6. doi: 10.1039/d4nh00287c. [Epub ahead of print] PubMed [citation] PMID: 39240547
  • Dong C, Zhu W, Wei L, Kim JK, Ma Y, Kang SM, Wang BZ. Enhancing cross-protection against influenza by heterologous sequential immunization with mRNA LNP and protein nanoparticle vaccines. Nat Commun. 2024 Jul 10;15(1):5800. doi: 10.1038/s41467-024-50087-5. PubMed [citation] PMID: 38987276, PMCID: PMC11237032
  • Dong C, Wang BZ. Advancing universal influenza vaccines: insights from cellular immunity targeting the conserved hemagglutinin stalk domain in humans. 2024 Jun;104:105172. doi: 10.1016/j.ebiom.2024.105172. Epub 2024 May 23. PubMed [citation] PMID: 38788629, PMCID: PMC11140559
  • Wei L, Dong C, Zhu W, Wang BZ. mRNA Vaccine Nanoplatforms and Innate Immunity. Viruses. 2024 Jan 14;16(1). doi: 10.3390/v16010120. Review. PubMed [citation] PMID: 38257820, PMCID: PMC10820759
  • Dong C, Ma Y, Zhu W, Wang Y, Kim J, Wei L, Gill HS, Kang SM, Wang BZ. Influenza immune imprinting synergizes PEI-HA/CpG nanoparticle vaccine protection against heterosubtypic infection in mice. Vaccine. 2024 Jan 12;42(2):111-119. doi: 10.1016/j.vaccine.2023.12.039. Epub 2023 Dec 14. PubMed [citation] PMID: 38097456, PMCID: PMC10842698
  • Zhu W, Park J, Pho T, Wei L, Dong C, Kim J, Ma Y, Champion JA, Wang BZ. ISCOMs/MPLA-Adjuvanted SDAD Protein Nanoparticles Induce Improved Mucosal Immune Responses and Cross-Protection in Mice. Small. 2023 Aug;19(34):e2301801. doi: 10.1002/smll.202301801. Epub 2023 May 10. PubMed [citation] PMID: 37162451, PMCID: PMC10524461
  • Zhu W, Wei L, Dong C, Wang Y, Kim J, Ma Y, Gonzalez GX, Wang BZ. cGAMP-adjuvanted multivalent influenza mRNA vaccines induce broadly protective immunity through cutaneous vaccination in mice. Mol Ther Nucleic Acids. 2022 Nov 9;30:421-437. doi: 10.1016/j.omtn.2022.10.024. eCollection 2022 Dec 13. PubMed [citation] PMID: 36420215, PMCID: PMC9668623
  • Wilks LR, Joshi G, Kang SM, Wang BZ, Gill HS. Peptide Cross-Linking Using Tyrosine Residues Facilitated by an Exogenous Nickel-Histidine Complex: A Facile Approach for Enhancing Vaccine-Specific Immunogenicity. ACS Infect Dis. 2022 Dec 9;8(12):2389-2395. doi: 10.1021/acsinfecdis.2c00265. Epub 2022 Nov 8. PubMed [citation] PMID: 36346898
  • Liu CC, Liu DJ, Yue XY, Zhong XQ, Wu X, Chang HY, Wang BZ, Wan MY, Deng L. Chimeric Virus-like Particles Co-Displaying Hemagglutinin Stem and the C-Terminal Fragment of DnaK Confer Heterologous Influenza Protection in Mice. Viruses. 2022 Sep 23;14(10). doi: 10.3390/v14102109. PubMed [citation] PMID: 36298664, PMCID: PMC9610613
  • Wang Y, Dong C, Ma Y, Zhu W, Gill HS, Denning TL, Kang SM, Wang BZ. Monophosphoryl lipid A-adjuvanted nucleoprotein-neuraminidase nanoparticles improve immune protection against divergent influenza viruses. 2023 Jan;47:102614. doi: 10.1016/j.nano.2022.102614. Epub 2022 Oct 17. PubMed [citation] PMID: 36265560, PMCID: PMC9756393
  • Bhatnagar N, Kim KH, Subbiah J, Park BR, Wang P, Gill HS, Wang BZ, Kang SM. Adjuvant Effects of a New Saponin Analog VSA-1 on Enhancing Homologous and Heterosubtypic Protection by Influenza Virus Vaccination. Vaccines (Basel). 2022 Aug 24;10(9). doi: 10.3390/vaccines10091383. PubMed [citation] PMID: 36146461, PMCID: PMC9501088
  • Kim KH, Li Z, Bhatnagar N, Subbiah J, Park BR, Shin CH, Pushko P, Wang BZ, Kang SM. Universal protection against influenza viruses by multi-subtype neuraminidase and M2 ectodomain virus-like particle. PLoS Pathog. 2022 Aug 25;18(8):e1010755. doi: 10.1371/journal.ppat.1010755. eCollection 2022 Aug. PubMed [citation] PMID: 36006890, PMCID: PMC9409530
  • Song Y, Zhu W, Wang Y, Deng L, Ma Y, Dong C, Gonzalez GX, Kim J, Wei L, Kang SM, Wang BZ. Layered protein nanoparticles containing influenza B HA stalk induced sustained cross-protection against viruses spanning both viral lineages. Biomaterials. 2022 Aug;287:121664. doi: 10.1016/j.biomaterials.2022.121664. Epub 2022 Jul 4. PubMed [citation] PMID: 35810540, PMCID: PMC9822777
  • Subbiah J, Oh J, Kim KH, Shin CH, Park BR, Bhatnagar N, Seong BL, Wang BZ, Kang SM. A chimeric thermostable M2e and H3 stalk-based universal influenza A virus vaccine. NPJ Vaccines. 2022 Jun 29;7(1):68. doi: 10.1038/s41541-022-00498-6. PubMed [citation] PMID: 35768475, PMCID: PMC9243060
  • Dong C, Wang BZ. Engineered Nanoparticulate Vaccines to Combat Recurring and Pandemic Influenza Threats. Adv Nanobiomed Res. 2022 Mar;2(3). pii: 2100122. doi: 10.1002/anbr.202100122. Epub 2021 Dec 7. PubMed [citation] PMID: 35754779, PMCID: PMC9231845
  • Subbbiah J, Oh J, Kim KH, Shin CH, Park BR, Bhatnagar N, Jung YJ, Lee Y, Wang BZ, Seong BL, Kang SM. Thermostable H1 hemagglutinin stem with M2e epitopes provides broad cross-protection against group1 and 2 influenza A viruses. Mol Ther Methods Clin Dev. 2022 May 29;26:38-51. doi: 10.1016/j.omtm.2022.05.007. eCollection 2022 Sep 8. PubMed [citation] PMID: 35755946, PMCID: PMC9198381
  • Ma Y, Wang Y, Dong C, Gonzalez GX, Zhu W, Kim J, Wei L, Kang SM, Wang BZ. SARS-CoV-2 Spike Stem Protein Nanoparticles Elicited Broad ADCC and Robust Neutralization against Variants in Mice. Small. 2022 Jun;18(25):e2200836. doi: 10.1002/smll.202200836. Epub 2022 May 23. PubMed [citation] PMID: 35607768, PMCID: PMC9233155
  • Dong C, Wang Y, Zhu W, Ma Y, Kim J, Wei L, Gonzalez GX, Wang BZ. Polycationic HA/CpG Nanoparticles Induce Cross-Protective Influenza Immunity in Mice. ACS Appl Mater Interfaces. 2022 Feb 9;14(5):6331-6342. doi: 10.1021/acsami.1c19192. Epub 2022 Jan 27. PubMed [citation] PMID: 35084819, PMCID: PMC8832387
  • Ma Y, Wang Y, Dong C, Gonzalez GX, Song Y, Zhu W, Kim J, Wei L, Wang BZ. Influenza NP core and HA or M2e shell double-layered protein nanoparticles induce broad protection against divergent influenza A viruses. 2022 Feb;40:102479. doi: 10.1016/j.nano.2021.102479. Epub 2021 Nov 4. PubMed [citation] PMID: 34743020, PMCID: PMC8897236
  • Jeeva S, Kim KH, Shin CH, Wang BZ, Kang SM. An Update on mRNA-Based Viral Vaccines. Vaccines (Basel). 2021 Aug 29;9(9). doi: 10.3390/vaccines9090965. Review. PubMed [citation] PMID: 34579202, PMCID: PMC8473183
  • Wang Y, Li S, Dong C, Ma Y, Song Y, Zhu W, Kim J, Deng L, Denning TL, Kang SM, Prausnitz MR, Wang BZ. Skin vaccination with dissolvable microneedle patches incorporating influenza neuraminidase and flagellin protein nanoparticles induces broad immune protection against multiple influenza viruses. ACS Appl Bio Mater. 2021 Jun 21;4(6):4953-4961. doi: 10.1021/acsabm.1c00240. Epub 2021 May 11. PubMed [citation] PMID: 34179728, PMCID: PMC8232372
  • Dong C, Wang Y, Gonzalez GX, Ma Y, Song Y, Wang S, Kang SM, Compans RW, Wang BZ. Intranasal vaccination with influenza HA/GO-PEI nanoparticles provides immune protection against homo- and heterologous strains. Proc Natl Acad Sci U S A. 2021 May 11;118(19). doi: 10.1073/pnas.2024998118. PubMed [citation] PMID: 33941704, PMCID: PMC8126854
  • Kim KH, Bhatnagar N, Jeeva S, Oh J, Park BR, Shin CH, Wang BZ, Kang SM. Immunogenicity and Neutralizing Activity Comparison of SARS-CoV-2 Spike Full-Length and Subunit Domain Proteins in Young Adult and Old-Aged Mice. Vaccines (Basel). 2021 Mar 29;9(4). doi: 10.3390/vaccines9040316. PubMed [citation] PMID: 33805473, PMCID: PMC8066235
  • Park BR, Kim KH, Kotomina T, Kim MC, Kwon YM, Jeeva S, Jung YJ, Bhatnagar N, Isakova-Sivak I, Mezhenskaya D, Rudenko L, Wang BZ, Kang SM. Broad cross protection by recombinant live attenuated influenza H3N2 seasonal virus expressing conserved M2 extracellular domain in a chimeric hemagglutinin. Sci Rep. 2021 Feb 18;11(1):4151. doi: 10.1038/s41598-021-83704-0. PubMed [citation] PMID: 33603072, PMCID: PMC7893060
  • Zhu W, Dong C, Wei L, Wang BZ. Promising Adjuvants and Platforms for Influenza Vaccine Development. 2021 Jan 7;13(1). doi: 10.3390/pharmaceutics13010068. Review. PubMed [citation] PMID: 33430259, PMCID: PMC7825707
  • Tang S, Zhu W, Wang BZ. Influenza Vaccines toward Universality through Nanoplatforms and Given by Microneedle Patches. Viruses. 2020 Oct 24;12(11). doi: 10.3390/v12111212. PubMed [citation] PMID: 33114336, PMCID: PMC7690886
  • Kim JK, Kang SM, Compans RW, Wang BZ. Are long-term influenza vaccines possible and how do we discover them? Expert Opin Drug Discov. 2021 Mar;16(3):213-216. doi: 10.1080/17460441.2021.1828859. Epub 2020 Oct 8. PubMed [citation] PMID: 33030353, PMCID: PMC7904565
  • Wang Y, Deng L, Gonzalez GX, Luthra L, Dong C, Ma Y, Zou J, Kang SM, Wang BZ. Double-Layered M2e-NA Protein Nanoparticle Immunization Induces Broad Cross-Protection against Different Influenza Viruses in Mice. Adv Healthc Mater. 2020 Jan;9(2):e1901176. doi: 10.1002/adhm.201901176. Epub 2019 Dec 15. PubMed PMID: 31840437, PMCID: PMC6980908
  • Ko EJ, Lee Y, Lee YT, Jung YJ, Ngo VL, Kim MC, Kim KH, Wang BZ, Gewirtz AT, Kang Flagellin-expressing virus-like particles exhibit adjuvant effects on promoting IgG isotype-switched long-lasting antibody induction and protection of influenza vaccines in CD4-deficient mice. Vaccine. 2019 Jun 6;37(26):3426-3434. doi: 10.1016/j.vaccine.2019.05.018. Epub 2019 May 14. PubMed [citation] PMID: 31101421, PMCID: PMC7274143
  • Deng L, Wang BZ. A Perspective on Nanoparticle Universal Influenza Vaccines. ACS Infect Dis. 2018 Dec 14;4(12):1656-1665. doi: 10.1021/acsinfecdis.8b00206. Epub 2018 Nov 15. Review. PubMed [citation] PMID: 30394725, PMCID: PMC8650199
  • Wang Y, Deng L, Kang SM, Wang BZ. Universal influenza vaccines: from viruses to nanoparticles. Expert Rev Vaccines. 2018 Nov;17(11):967-976. doi: 10.1080/14760584.2018.1541408. Epub 2018 Nov 2. Review. PubMed [citation] PMID: 30365905, PMCID: PMC6300164
  • Wang Y, Jung YJ, Kim KH, Kwon Y, Kim YJ, Zhang Z, Kang HS, Wang BZ, Quan FS, Kang SM. Antiviral Activity of Fermented Ginseng Extracts against a Broad Range of Influenza Viruses. 2018 Sep 1;10(9). doi: 10.3390/v10090471. PubMed [citation] PMID: 30200514, PMCID: PMC6164659
  • Kim KH, Kwon YM, Lee YT, Hwang HS, Kim MC, Ko EJ, Wang BZ, Quan FS, Kang SM. Virus-like particles presenting flagellin exhibit unique adjuvant effects on eliciting T helper type 1 humoral and cellular immune responses to poor immunogenic influenza virus M2e protein vaccine. Virology. 2018 Nov;524:172-181. doi: 10.1016/j.virol.2018.08.019. Epub 2018 Sep 7. PubMed [citation] PMID: 30199754, PMCID: PMC6190693
  • Zhu W, Li S, Wang C, Yu G, Prausnitz MR, Wang BZ. Enhanced Immune Responses Conferring Cross-Protection by Skin Vaccination With a Tri-Component Influenza Vaccine Using a Microneedle Patch. Front Immunol. 2018 Jul 30;9:1705. doi: 10.3389/fimmu.2018.01705. eCollection 2018. PubMed [citation] PMID: 30105019, PMCID: PMC6077188
  • Chang TZ, Deng L, Wang BZ, Champion JA. H7 Hemagglutinin nanoparticles retain immunogenicity after >3 months of 25°C storage. PLoS One. 2018 Aug 9;13(8):e0202300. doi: 10.1371/journal.pone.0202300. eCollection 2018. PubMed [citation] PMID: 30092060, PMCID: PMC6084952
  • Deng L, Chang TZ, Wang Y, Li S, Wang S, Matsuyama S, Yu G, Compans RW, Li JD, Prausnitz MR, Champion JA, Wang BZ. Heterosubtypic influenza protection elicited by double-layered polypeptide nanoparticles in mice. Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7758-E7767. doi: 10.1073/pnas.1805713115. Epub 2018 Jul 31. PubMed [citation] PMID: 30065113, PMCID: PMC6099848
  • Mohan T, Berman Z, Kang SM, Wang BZ. Sequential immunizations with a panel of HIV-1 Env virus-like particles coach immune system to make broadly neutralizing antibodies. Sci Rep. 2018 May 17;8(1):7807. doi: 10.1038/s41598-018-25960-1. PubMed [citation] PMID: 29773829, PMCID: PMC5958130
  • Wang C, Zhu W, Luo Y, Wang BZ. Gold nanoparticles conjugating recombinant influenza hemagglutinin trimers and flagellin enhanced mucosal cellular immunity. 2018 Jun;14(4):1349-1360. doi: 10.1016/j.nano.2018.03.007. Epub 2018 Apr 9. PubMed [citation] PMID: 29649593, PMCID: PMC6177327
  • Luo Y, Mohan T, Zhu W, Wang C, Deng L, Wang BZ. Sequential Immunizations with heterosubtypic virus-like particles elicit cross protection against divergent influenza A viruses in mice. Sci Rep. 2018 Mar 15;8(1):4577. doi: 10.1038/s41598-018-22874-w. PubMed [citation] PMID: 29545521, PMCID: PMC5854580
  • Deng L, Mohan T, Chang TZ, Gonzalez GX, Wang Y, Kwon YM, Kang SM, Compans RW, Champion JA, Wang BZ. Double-layered protein nanoparticles induce broad protection against divergent influenza A viruses. Nat Commun. 2018 Jan 24;9(1):359. doi: 10.1038/s41467-017-02725-4. PubMed [citation] PMID: 29367723, PMCID: PMC5783933
  • Gangadhara S, Kwon YM, Jeeva S, Quan FS, Wang B, Moss B, Compans RW, Amara RR, Jabbar MA, Kang SM. Vaccination with Combination DNA and Virus-Like Particles Enhances Humoral and Cellular Immune Responses upon Boost with Recombinant Modified Vaccinia Virus Ankara Expressing Human Immunodeficiency Virus Envelope Proteins. Vaccines (Basel). 2017 Dec 19;5(4). doi: 10.3390/vaccines5040052. PubMed [citation] PMID: 29257056, PMCID: PMC5748618
  • Mohan T, Zhu W, Wang Y, Wang BZ. Applications of chemokines as adjuvants for vaccine immunotherapy. 2018 Jun-Jul;223(6-7):477-485. doi: 10.1016/j.imbio.2017.12.001. Epub 2017 Dec 8. PubMed [citation] PMID: 29246401, PMCID: PMC5894355
  • Mohan T, Deng L, Wang BZ. CCL28 chemokine: An anchoring point bridging innate and adaptive immunity. Int Immunopharmacol. 2017 Oct;51:165-170. doi: 10.1016/j.intimp.2017.08.012. Epub 2017 Aug 30. Review. PubMed [citation] PMID: 28843907, PMCID: PMC5755716
  • Wang C, Zhu W, Wang BZ. Dual-linker gold nanoparticles as adjuvanting carriers for multivalent display of recombinant influenza hemagglutinin trimers and flagellin improve the immunological responses in vivo and in vitro. Int J Nanomedicine. 2017 Jul 4;12:4747-4762. doi: 10.2147/IJN.S137222. eCollection 2017. PubMed [citation] PMID: 28740382, PMCID: PMC5503497
  • Zhu W, Wang C, Wang BZ. From Variation of Influenza Viral Proteins to Vaccine Development. Int J Mol Sci. 2017 Jul 18;18(7). doi: 10.3390/ijms18071554. PubMed [citation] PMID: 28718801, PMCID: PMC5536042
  • Zhu W, Pewin W, Wang C, Luo Y, Gonzalez GX, Mohan T, Prausnitz MR, Wang BZ. A boosting skin vaccination with dissolving microneedle patch encapsulating M2e vaccine broadens the protective efficacy of conventional influenza vaccines. J Control Release. 2017 Sep 10;261:1-9. doi: 10.1016/j.jconrel.2017.06.017. Epub 2017 Jun 19. PubMed [citation] PMID: 28642154, PMCID: PMC5567859
  • Deng L, Kim JR, Chang TZ, Zhang H, Mohan T, Champion JA, Wang BZ. Protein nanoparticle vaccine based on flagellin carrier fused to influenza conserved epitopes confers full protection against influenza A virus challenge. Virology. 2017 Sep;509:82-89. doi: 10.1016/j.virol.2017.06.001. Epub 2017 Jun 13. PubMed [citation] PMID: 28622575, PMCID: PMC5526067
  • Chang TZ, Diambou I, Kim JR, Wang B, Champion JA. Host- and pathogen-derived adjuvant coatings on protein nanoparticle vaccines. Bioeng Transl Med. 2017 Mar;2(1):120-130. doi: 10.1002/btm2.10052. Epub 2017 Feb 3. PubMed [citation] PMID: 28516165, PMCID: PMC5412930
  • Mohan T, Berman Z, Luo Y, Wang C, Wang S, Compans RW, Wang BZ. Chimeric virus-like particles containing influenza HA antigen and GPI-CCL28 induce long-lasting mucosal immunity against H3N2 viruses. Sci Rep. 2017 Jan 9;7:40226. doi: 10.1038/srep40226. PubMed [citation] PMID: 28067290, PMCID: PMC5220311
  • Wang L, Chang TZ, He Y, Kim JR, Wang S, Mohan T, Berman Z, Tompkins SM, Tripp RA, Compans RW, Champion JA, Wang BZ. Coated protein nanoclusters from influenza H7N9 HA are highly immunogenic and induce robust protective immunity. Nanomedicine. 2017 Jan;13(1):253-262. doi: 10.1016/j.nano.2016.09.001. Epub 2016 Sep 10. PubMed [citation] PMID: 27622321, PMCID: PMC5237404
  • Mohan T, Kim J, Berman Z, Wang S, Compans RW, Wang BZ. Co-delivery of GPI-anchored CCL28 and influenza HA in chimeric virus-like particles induces cross-protective immunity against H3N2 viruses. J Control Release. 2016 Jul 10;233:208-19. doi: 10.1016/j.jconrel.2016.05.021. Epub 2016 May 10. PubMed [citation] PMID: 27178810, PMCID: PMC4912934
  • Vzorov AN, Wang L, Chen J, Wang BZ, Compans RW. Effects of modification of the HIV-1 Env cytoplasmic tail on immunogenicity of VLP vaccines. Virology. 2016 Feb;489:141-50. doi: 10.1016/j.virol.2015.09.015. Epub 2016 Jan 4. PubMed [citation] PMID: 26761396
  • Feng H, Zhang H, Deng J, Wang L, He Y, Wang S, Seyedtabaei R, Wang Q, Liu L, Galipeau J, Compans RW, Wang BZ. Incorporation of a GPI-anchored engineered cytokine as a molecular adjuvant enhances the immunogenicity of HIV VLPs. Sci Rep. 2015 Jul 7;5:11856. doi: 10.1038/srep11856. PubMed [citation] PMID: 26150163, PMCID: PMC4493578
  • Ou C, Shi N, Yang Q, Zhang Y, Wu Z, Wang B, Compans RW, He C. Protocatechuic acid, a novel active substance against avian influenza virus H9N2 infection. PLoS One. 2014 Oct 22;9(10):e111004. doi: 10.1371/journal.pone.0111004. eCollection 2014. PubMed [citation] PMID: 25337912, PMCID: PMC4206475
  • Zhang H, Wang L, Compans RW, Wang BZ. Universal influenza vaccines, a dream to be realized soon. Viruses. 2014 Apr 29;6(5):1974-91. doi: 10.3390/v6051974. PubMed [citation] PMID: 24784572, PMCID: PMC4036552
  • Wang BZ, Gill HS, He C, Ou C, Wang L, Wang YC, Feng H, Zhang H, Prausnitz MR, Compans RW. Microneedle delivery of an M2e-TLR5 ligand fusion protein to skin confers broadly cross-protective influenza immunity. J Control Release. 2014 Mar 28;178:1-7. doi: 10.1016/j.jconrel.2014.01.002. Epub 2014 Jan 11. PubMed [citation] PMID: 24417966, PMCID: PMC3951682
  • Wang L, Hess A, Chang TZ, Wang YC, Champion JA, Compans RW, Wang BZ. Nanoclusters self-assembled from conformation-stabilized influenza M2e as broadly cross-protective influenza vaccines. Nanomedicine. 2014 Feb;10(2):473-82. doi:10.1016/j.nano.2013.08.005. Epub 2013 Aug 27. PubMed [citation] PMID: 23988715, PMCID: PMC3948190
  • Wang L, Wang YC, Feng H, Ahmed T, Compans RW, Wang BZ. Virus-like particles containing the tetrameric ectodomain of influenza matrix protein 2 and flagellin induce heterosubtypic protection in mice. Biomed Res Int. 2013;2013:686549. doi:  1155/2013/686549. Epub 2013 Jul 30. PubMed [citation] PMID: 23984396, PMCID: PMC3745920
  • Kim MC, Lee JS, Kwon YM, O E, Lee YJ, Choi JG, Wang BZ, Compans RW, Kang SM. Multiple heterologous M2 extracellular domains presented on virus-like particles confer broader and stronger M2 immunity than live influenza A virus infection. Antiviral Res. 2013 Sep;99(3):328-35. doi: 10.1016/j.antiviral.2013.06.010. Epub  2013 Jun 27. PubMed [citation] PMID: 23811283, PMCID: PMC3788098
  • Wang BZ, Gill HS, Kang SM, Wang L, Wang YC, Vassilieva EV, Compans RW. Enhanced influenza virus-like particle vaccines containing the extracellular domain of matrix protein 2 and a Toll-like receptor ligand. Clin Vaccine Immunol. 2012 Aug;19(8):1119-25. doi: 10.1128/CVI.00153-12. Epub 2012 May 30. PubMed [citation] PMID: 22647270, PMCID: PMC3416094
  • Yoo DG, Kim MC, Park MK, Park KM, Quan FS, Song JM, Wee JJ, Wang BZ, Cho YK, Compans RW, Kang SM. Protective effect of ginseng polysaccharides on influenza viral infection. PLoS One. 2012;7(3):e33678. doi: 10.1371/journal.pone.0033678. Epub 2012 Mar 19. PubMed [citation] PMID: 22442708, PMCID: PMC3307756
  • Chaung HC, Cheng LT, Hung LH, Tsai PC, Skountzou I, Wang B, Compans RW, Lien YY. Salmonella flagellin enhances mucosal immunity of avian influenza vaccine in chickens. Vet Microbiol. 2012 May 25;157(1-2):69-77. doi: 10.1016/j.vetmic.2011.12.014. Epub 2011 Dec 16. PubMed [citation] PMID: 22226542
  • Vassilieva EV, Wang BZ, Vzorov AN, Wang L, Wang YC, Bozja J, Xu R, Compans RW. Enhanced mucosal immune responses to HIV virus-like particles containing a membrane-anchored adjuvant. mBio. 2011 Feb 15;2(1):e00328-10. doi: 10.1128/mBio.00328-10. Print 2011. PubMed [citation] PMID: 21325038, PMCID: PMC3039440
  • Weldon WC, Martin MP, Zarnitsyn V, Wang B, Koutsonanos D, Skountzou I, Prausnitz MR, Compans RW. Microneedle vaccination with stabilized recombinant influenza virus hemagglutinin induces improved protective immunity. Clin Vaccine Immunol. 2011 Apr;18(4):647-54. doi: 10.1128/CVI.00435-10. Epub 2011 Feb 2. PubMed [citation] PMID: 21288996, PMCID: PMC3122571
  • Song JM, Wang BZ, Park KM, Van Rooijen N, Quan FS, Kim MC, Jin HT, Pekosz A, Compans RW, Kang SM. Influenza virus-like particles containing M2 induce broadly cross protective immunity. PLoS One. 2011 Jan 18;6(1):e14538. doi: 10.1371/journal.pone.0014538. PubMed [citation] PMID: 21267073, PMCID: PMC3022578
  • Wang BZ, Xu R, Quan FS, Kang SM, Wang L, Compans RW. Intranasal immunization with influenza VLPs incorporating membrane-anchored flagellin induces strong heterosubtypic protection. PLoS One. 2010 Nov 29;5(11):e13972. doi: 10.1371/journal.pone.0013972. PubMed [citation] PMID: 21124769, PMCID: PMC2993933
  • Paust S, Gill HS, Wang BZ, Flynn MP, Moseman EA, Senman B, Szczepanik M, Telenti A, Askenase PW, Compans RW, von Andrian UH. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol. 2010 Dec;11(12):1127-35. doi: 10.1038/ni.1953. Epub 2010 Oct 24. PubMed [citation] PMID: 20972432, PMCID: PMC2982944
  • Weldon WC, Wang BZ, Martin MP, Koutsonanos DG, Skountzou I, Compans RW. Enhanced immunogenicity of stabilized trimeric soluble influenza hemagglutinin. PLoS One. 2010 Sep 1;5(9). pii: e12466. doi: 10.1371/journal.pone.0012466. PubM [citation] PMID: 20824188, PMCID: PMC2931692
  • Skountzou I, Martin Mdel P, Wang B, Ye L, Koutsonanos D, Weldon W, Jacob J, Compans RW. Salmonella flagellins are potent adjuvants for intranasally administered whole inactivated influenza vaccine. Vaccine. 2010 May 28;28(24):4103-12. doi: 10.1016/j.vaccine.2009.07.058. Epub 2009 Aug 3. PubMed [citation] PMID: 19654062, PMCID: PMC3187848
  • Wang BZ, Quan FS, Kang SM, Bozja J, Skountzou I, Compans RW. Incorporation of membrane-anchored flagellin into influenza virus-like particles enhances the breadth of immune responses. J Virol. 2008 Dec;82(23):11813-23. doi: 10.1128/JVI.01076-08. Epub 2008 Sep 10. PubMed [citation] PMID: 18786995, PMCID: PMC2583664
  • Wang BZ, Liu W, Kang SM, Alam M, Huang C, Ye L, Sun Y, Li Y, Kothe DL, Pushko P, Dokland T, Haynes BF, Smith G, Hahn BH, Compans RW. Incorporation of high levels of chimeric human immunodeficiency virus envelope glycoproteins into virus-like particles. J Virol. 2007 Oct;81(20):10869-78. Epub 2007 Aug 1. PubMed [citation]  PMID: 17670815, PMCID: PMC2045522
  • Wang BZ, Zou WG, Liu WY, Liu XY. The lower cytotoxicity of cinnamomin (a type II RIP) is due to its B-chain. Arch Biochem Biophys. 2006 Jul 1;451(1):91-6. Epub 2006 May 6. PubMed [citation] PMID: 16762311
  • Wang BZ, Wei XB, Liu WY. Cleavage of supercoiled circular double-stranded DNA induced by a eukaryotic cambialistic superoxide dismutase from Cinnamomum camphora. Acta Biochim Biophys Sin (Shanghai). 2004 Sep;36(9):609-17. PubMed [citation] PMID: 15346198
  • Xu H, Wang BZ, Liu WY. Comparative study of interaction of two type II ribosome-inactivating proteins and their A-chains with model membrane. Protein Pept Lett. 2004 Apr;11(2):157-63. PubMed [citation] PMID: 15078204
  • Wang BZ, Liu WY. Refolding of partially thermo-unfolded cinnamomin A-chain mediated by B-chain. Biochem Biophys Res Commun. 2003 Jun 20;306(1):39-45. PubMed [citation] PMID: 12788063
  • Chen HY, Hu RG, Wang BZ, Chen WF, Liu WY, Schröder W, Frank P, Ulbrich N. Structural studies of an eukaryotic cambialistic superoxide dismutase purified from the mature seeds of camphor tree. Arch Biochem Biophys. 2002 Aug 15;404(2):218-26. PubMed [citation] PMID: 12147259
  • Xie L, Wang BZ, Hu RG, Ji HB, Zhang L, Liu WY. Structural and functional studies of cinnamomin, a new type II ribosome-inactivating protein isolated from the seeds of the camphor tree. Eur J Biochem. 2001 Nov;268(22):5723-33. PubMed [citation] PMID: 11722556

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