Patricia Denning
Adjunct Faculty Adjunct Associate Professor Institute for Biomedical Sciences- Education
M.D. Baylor College of Medicine, Houston, TX 1991-1995
Resident in Pediatrics, Baylor College of Medicine, Houston, TX 1995-1997
Resident in Pediatrics, Boston University Medical School, Boston, MA 1997-1998
Fellow in Neonatology, Harvard Medical School, Boston, MA 1998-2001
GI Research Fellowship, Harvard Medical School, Boston, MA 1999-2002
- Biography
Patricia Denning, adjunct professor at Georgia State University and assistant professor in neonatal-perinatal medicine at Emory University, focuses her research on understanding how the development of host defenses is regulated in the neonatal intestine. In particular, she is interested in understanding how immature intestinal host defenses can predispose premature infants to develop necrotizing enterocolitis (NEC).
Dr. Denning earned her M.D. from Baylor College of Medicine in Houston, Texas and completed her Pediatric Residency training at Baylor College of Medicine and Boston University Medical School. She completed her clinical neonatology fellowship in neonatology and gastroenterology research fellowship at Harvard Medical School.
Research Interests
Developmental Regulation of Intestinal Innate Immunity
Necrotizing enterocolitis (NEC) is a leading cause of neonatal morbidity and mortality primarily affecting premature infants. Epidemiologic studies indicate that NEC onset peaks at 32 weeks postconceptual age implicating a developmental period of susceptibility. Although the exact etiology of NEC is unclear, immature intestinal defenses and abnormal bacterial colonization are thought to play key roles in NEC pathogenesis. Our laboratory is specifically interested in bacterial-host interactions and how normal bacterial colonization may influence maturation of intestinal innate immune responses.
- Publications
Selected
- Jakaitis BM, Denning PW. Human Breast Milk and the Gastrointestinal Innate Immune System. Clin Perinatol, 2014 In Press.
- Jakaitis BM, Denning PW. Commensal and Probiotic Bacteria May Prevent NEC by Maturing Intestinal Host Defenses. Pathophysiology. 2014 Jan 16. pii: S0928-4680(13)00077-1. doi: 10.1016/j.pathophys.2013.11.012. [Epub ahead of print]
- Neumann PA, Kock S, Hilgarth RS, Perez-Chanona E, Denning PW, Jobin C, Nusrat A. Gut commensal bacteria and regional Wnt gene expression patterns in the proximal versus distal colon. Am J Pathol. 2014 Jan 10, Epub ahead of print.
- Neumann PA, Kock S, Hilgarth RS, Perez-Chanona E, Denning PW, Jobin C, Nusrat A. Gut commensal bacteria and regional Wnt gene expression patterns in the proximal versus distal colon. Am J Pathol. 2014 Jan 10, Epub ahead of print.
- Patel RM, Denning PW. Therapeutic Use of Prebiotics, Probiotics, and Postbiotics to Prevent Necrotizing Enterocolitis: What is the Current Evidence? Clin Perinatol. 2013 Mar;40(1):11-25. Epub 2013 Jan 17.
- Denning PW, Maheshwari A. Necrotizing enterocolitis: hope on the horizon. Clin Perinatol. 2013 Mar;40(1):xvii-xix.
- Jones RM, Luo L, Ardita CS, Richardson AN, Kwon Y-M, Mercante JW, Alam A, Gates CL, Wu H, Philip A, Swanson PA, Lambeth JD, Denning PW, and Neish AS. Symbiotic Lactobacilli stimulate gut epithelial proliferation via Nox-mediated generation of reactive oxygen species. EMBO Journal. 2013 Nov 27;32(23):3017-28, Epub 2013 Oct 18.
- Mirpuri J, Sotnikov I, Myers L, Denning TL, Yarovinsky F, Parkos CA, Denning PW, Louis NA. Lactobacillus rhamnosus (LGG) regulates IL-10 signaling in the developing murine colon through upregulation of the IL-10R2 receptor subunit. Plos One. 2012;7(12):e51955. Epub 2012 Dec 18.
- Patel RM, Lin PW. Developmental Biology of Gut-Probiotic Interaction. Gut Microbes. 2010 May/Jun: 1(3): 186-195.
- MirpuriJ, BrazilJC, BerardinelliAJ, NasrTR, CooperK, SchnoorM, LinPW, ParkosCA, Louis NA. Commensal Escherichia coli reduces epithelial apoptosis through interferon alpha-A mediated induction of guanylate binding protein-1 in human and murine models of developing intestine. Journal of Immunology. 2010 Jun 15:184(12):7186-95. Epub 2010 May 14.
- Lin PW*, Myers LES, Ray L, Song Shuh-Chyung, Nasr TR, Berardinelli AJ, Kundu K, Murthy N, Hansen JM, Neish AS. Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation. Free Radical Biology and Medicine. 2009 Oct 15;47(8):1205-11. Epub 2009 Aug 3.
- Louis NA, Lin PW. The Intestinal Immune Barrier. NeoReviews 2009; 10(4):e180.
- Lin PW*, Nasr TR, Berardinelli AJ, Kumar A, Neish AS. The probiotic Lactobacillus rhamnosus GG may augment intestinal host defense by regulating apoptosis and promoting cytoprotective responses in the developing murine gut. Pediatr Res. 2008 Nov; 64(5):511-6. Epub 2008 Jun 11.
- Lin PW*, Nasr TR, Stoll BJ. Necrotizing Enterocolitis: Recent Scientific Advances in Pathophysiology and Prevention. Semin Perinatol. 2008 Apr; 32(2):70-82.
- Lin PW, Stoll BJ. Necrotizing Enterocolitis. The Lancet. 2006 Oct 7; 368(9543):1271-83.
- Zeng H, Wu H, Sloane V, Jones R, Yu Y, Lin P, Gewirtz AT, Neish AS. Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways. Am J Physiol Gastrointest Liver Physiol. 2006 Jan; 290(1):G96-108. Epub 2005 Sep 22.
- Lin PW, Simon PO Jr, Gewirtz AT, Neish AS, Ouellette AJ, Madara JL, Lencer, WI. Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response. J Biol Chem. 2004 May 7; 279(19):19902-7. Epub 2004 Feb 27.
- Lin PW, Rufo PA, Andrade A, Jiang L, Rameh L, Flexner CW, Alper SL, Lencer WI. Diarrhea-associated HIV-1 aspartyl protease-inhibitors potentiate muscarinic Cl- secretion by T84 cells via prolongation of cytosolic Ca2+ signaling. Am J Physiol Cell Physiol. 2004 May; 286(5):C998-C1008. Epub 2003 Dec 30.
- Rodgers PA, Seidman DS, Wei PL, Dennery PA, Stevenson DK. Duration of Action and Tissue Distribution of Zinc Protoporphyrin in Neonatal Rats. Pediatric Research 1996; 39(6): 1041-9.